Our lab helped redefine the PKS module and is now using this updated definition to engineer modular PKSs that efficiently produce novel polyketides! Take a look at our work:

Keatinge-Clay, A.T. (2017). Polyketide synthase modules redefined.
Angew. Chem. Int. Ed. Engl. 56:4658-4660.

Vander Wood, D.A. & Keatinge-Clay, A.T. (2018). The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.
Proteins 86:664-675.

Miyazawa, T., Hirsch, M., Zhang, Z., Keatinge-Clay, A.T. (2020). An in vitro platform for studying and harnessing modular polyketide synthases.
Nat. Commun. 1:80.