Our lab helped redefine the PKS module and is now using this updated definition to engineer modular PKSs that efficiently produce novel polyketides! Check out our science through YouTube or our publications:

Keatinge-Clay, A.T. (2017). Polyketide synthase modules redefined.
Angew. Chem. Int. Ed. Engl. 56:4658-4660.

Vander Wood, D.A. & Keatinge-Clay, A.T. (2018). The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.
Proteins 86:664-675.

Miyazawa, T., Hirsch, M., Zhang, Z., Keatinge-Clay, A.T. (2020). An in vitro platform for engineering and harnessing modular polyketide synthases.
Nat. Commun. 1:80.

Miyazawa, T., Fitzgerald, B.F., Keatinge-Clay, A.T. (2021). Preparative production of an enantiomeric pair by engineered assembly lines.
Chem. Commun. 57:8762-8765.

Hirsch, M., Fitzgerald, B.F., Keatinge-Clay, A.T. (2021). How cis-acyltransferase assembly-line ketosynthases gatekeep for processed polyketide intermediates.
ACS Chem. Biol. DOI: 10.1021/acschembio.1c00598